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ARTICLES
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1901-1909
Application of Similarity Matrices and Genetic Neural Networks in Quantitative Structure-Activity Relationships of 2- or 4-(4-Methylpiperazino)pyrimidines: 5-HT2A Receptor Antagonists
Tomasz Borowski,
Marcin Król,
Ewa Broc awik,
Timothy C. Baranowski,
Lucjan Strekowski, and
Maria J. Mokrosz
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1910-1926
Design and Synthesis of Cyclopenta[g]quinazoline-Based Antifolates as Inhibitors of Thymidylate Synthase and Potential Antitumor Agents
Vassilios Bavetsias,
Jonathan H. Marriott,
Camille Melin,
Rosemary Kimbell,
Zbigniew S. Matusiak,
F. Thomas Boyle, and
Ann L. Jackman
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1927-1939
Synthesis and Evaluation of "AZT-HEPT", "AZT-Pyridinone", and "ddC-HEPT" Conjugates as Inhibitors of HIV Reverse Transcriptase
Renée Pontikis,
Valérie Dollé,
Jean Guillaumel,
Elsa Dechaux,
Reine Note,
Chi Hung Nguyen,
Michel Legraverend,
Emile Bisagni,
Anne-Marie Aubertin,
David S. Grierson, and
Claude Monneret
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1940-1948
1,3,5-Trialkyl-2,4,6-triiodobenzenes: Novel X-ray Contrast Agents for Gastrointestinal Imaging
Kimberly G. Estep,,2
Kurt A. Josef,
Edward R. Bacon,2
Carl R. Illig,2
John L. Toner,2
Dinesh Mishra,
William F. Blazak,
Dennis M. Miller,4
David K. Johnson,
Jack M. Allen,
Andy Spencer,4 and
Susan A. Wilson4
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1949-1957
Modeling of the Inhibition of Retroviral Integrases by Styrylquinoline Derivatives
Mohammed Ouali,
Cyril Laboulais,
Hervé Leh,
David Gill,
Didier Desmaële,
Khalid Mekouar,
Fatima Zouhiri,
Jean d'Angelo,
Christian Auclair,
Jean-François Mouscadet, and
Marc Le Bret
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1958-1968
4-Alkyl- and 4-Cinnamylglutamic Acid Analogues Are Potent GluR5 Kainate Receptor Agonists
Concepción Pedregal,
Iván Collado,
Ana Escribano,
Jesús Ezquerra,
Carmen Domínguez,
Ana I. Mateo,
Almudena Rubio,
S. Richard Baker,
John Goldsworthy,
Rajender K. Kamboj,
Barbara A. Ballyk,
Ken Hoo, and
David Bleakman
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1969-1974
Design, Synthesis, and Preliminary Pharmacological Evaluation of 1,4-Diazabicyclo[4.3.0]nonan-9-ones as a New Class of Highly Potent Nootropic Agents
Dina Manetti,
Carla Ghelardini,
Alessandro Bartolini,
Cristina Bellucci,
Silvia Dei,
Nicoletta Galeotti,
Fulvio Gualtieri,
Maria Novella Romanelli,
Serena Scapecchi, and
Elisabetta Teodori
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1975-1985
A Novel Approach for the Virtual Screening and Rational Design of Anticancer Compounds
Ernesto Estrada,
Eugenio Uriarte,
Alina Montero,
Marta Teijeira,
Lourdes Santana, and
Erik De Clercq
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1986-1992
Biosensor Analysis of the Interaction between Immobilized Human Serum Albumin and Drug Compounds for Prediction of Human Serum Albumin Binding Levels
Åsa Frostell-Karlsson,
Annika Remaeus,
Håkan Roos,
Karl Andersson,
Peter Borg,
Markku Hämäläinen, and
Robert Karlsson
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1993-2006
Quantized Surface Complementarity Diversity (QSCD): A Model Based on Small Molecule-Target Complementarity
Edward A. Wintner and
Ciamac C. Moallemi
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2007-2018
SAR of 9-Amino-1,2,3,4-tetrahydroacridine-Based Acetylcholinesterase Inhibitors: Synthesis, Enzyme Inhibitory Activity, QSAR, and Structure-Based CoMFA of Tacrine Analogues
Maurizio Recanatini,
Andrea Cavalli,
Federica Belluti,
Lorna Piazzi,
Angela Rampa,
Alessandra Bisi,
Silvia Gobbi,
Piero Valenti,
Vincenza Andrisano,
Manuela Bartolini, and
Vanni Cavrini
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2019-2030
Inhibition of Clinically Relevant Mutant Variants of HIV-1 by Quinazolinone Non-Nucleoside Reverse Transcriptase Inhibitors
Jeffrey W. Corbett,
Soo S. Ko,
James D. Rodgers,
Lisa A. Gearhart,
Nicholas A. Magnus,
Lee T. Bacheler,
Sharon Diamond,
Susan Jeffrey,
Ronald M. Klabe,
Beverly C. Cordova,
Sena Garber,
Kelly Logue,
George L. Trainor,
Paul S. Anderson, and
Susan K. Erickson-Viitanen
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2031-2039
A New Class of HIV-1 Integrase Inhibitors: The 3,3,3',3'-Tetramethyl-1,1'-spirobi(indan)-5,5',6,6'-tetrol Family
Valentina Molteni,
Denise Rhodes,
Kathleen Rubins,
Mark Hansen,
Frederic D. Bushman, and
Jay S. Siegel
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2040-2048
Novel Antiarthritic Agents with 1,2-Isothiazolidine-1,1-dioxide ( -Sultam) Skeleton: Cytokine Suppressive Dual Inhibitors of Cyclooxygenase-2 and 5-Lipoxygenase
Masanao Inagaki,
Tatsuo Tsuri,
Hirokuni Jyoyama,
Takashi Ono,
Katsutoshi Yamada,
Mika Kobayashi,
Yozo Hori,
Akinori Arimura,
Kiyoshi Yasui,
Kouji Ohno,
Shinji Kakudo,
Kenzo Koizumi,
Ryuji Suzuki,
Miyako Kato,
Shinichi Kawai, and
Saichi Matsumoto
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2049-2063
Discovery of Novel, Potent, and Selective Small-Molecule CCR5 Antagonists as Anti-HIV-1 Agents: Synthesis and Biological Evaluation of Anilide Derivatives with a Quaternary Ammonium Moiety
Mitsuru Shiraishi,
Yoshio Aramaki,
Masaki Seto,
Hiroshi Imoto,
Youichi Nishikawa,
Naoyuki Kanzaki,
Mika Okamoto,
Hidekazu Sawada,
Osamu Nishimura,
Masanori Baba, and
Masahiko Fujino
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2064-2071
Novel Conformationally Constrained Tropane Analogues by 6-endo-trig Radical Cyclization and Stille Coupling - Switch of Activity toward the Serotonin and/or Norepinephrine Transporter
Alexander Hoepping,
Kenneth M. Johnson,
Clifford George,
Judith Flippen-Anderson, and
Alan P. Kozikowski
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BRIEF ARTICLES
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2072-2078
Structure-Activity Study on the in Vitro Antiprotozoal Activity of Glutathione Derivatives
Claudius D'Silva and
Sylvie Daunes
, Peter Rock,
Vanessa Yardley, and
Simon L. Croft
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2079-2081
7-Methyl-6,7,8,9,14,15-hexahydro-5H-benz[d]indolo[2,3-g]azecine: A New Heterocyclic System and a New Lead Compound for Dopamine Receptor Antagonists
Thomas Witt,
Franz J. Hock, and
Jochen Lehmann
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BOOK REVIEWS
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2082-2082
| Combinatorial Chemistry and Technology. Principles, Methods, and Applications Edited by Stanislav Miertus and Giorgio Fassina. Marcel Dekker, New York. 1999. xii + 435 pp. 16 x 23.5 cm. ISBN 0-8247-1960-3. $165.00.
Robert G. Gentles
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